IDEXX Reference Laboratories
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IDEXX histopathology services
IDEXX histopathology services provide you with the most accurate and timely biopsy results to allow you to make a confident diagnosis and treatment plan.
- Let our highly specialised IDEXX histopathology technicians provide you with expert sample processing – decalcification when needed, trimming, dissection and quality slide preparation.
- Access the largest network of anatomic pathologists worldwide who provide quality interpretations, evaluation of surgical margins and special stains, as well as include comments regarding biological behaviour and aetiology.
- Consult directly by phone or email with the pathologist working on your case.
- View or share high-resolution images in VetConnect PLUS.
- Access comprehensive histopathology educational resources .
What's new.
Reference laboratory submissions – Ocular Pathology Service
- Ocular samples can be submitted under the test codes HISTOC (small animal) and HISTOCL (large animal).
- These are automatically read by our ocular specialty team of pathologists.
- Includes automatic application of Alcian blue-PAS special stain for assessment of vitreous, lens capsule and blood vessel changes.
- Ensures a fully comprehensive and detailed ocular pathology report with improved formatting.
Comprehensive testing services to cover even your most time‑sensitive cases.
Results in 36 hours (Monday–Thursday)
- Faster turnaround for your critical cases
- Personalised guidance from our team of expert pathologists
Test code: UHIS
See the online Directory of Tests and Services at vetconnectplus.co.uk
for test codes for additional sites/lesions.
Results in 2–5 days (Monday–Friday)
- Quick, reliable turnaround for your nonemergency cases
- Personalised guidance from our team of expert pathologists
Test codes
HIST1: 1 Site/Lesion
HIST2: 2 Sites/Lesions
See the online Directory of Tests and Services at vetconnectplus.co.uk
for test codes for additional sites/lesions.
Results in 2–14 days; results typically final within 7 days unless extended processing is required (particularly for samples involving bone)
- A thorough evaluation of organs (with or without bone) or large and large biopsies (e.g., spleen, liver and lung lobe; mammary chain; eye; bone biopsies [amputated limbs/digits/tails/jaws (whole or partial)])
- Personalised guidance from our team of expert pathologists
- Streamlined submission process, with one test code to cover all sites
Test code HISTLARGE
The Histology Liver Profile ensures comprehensive assessment of hepatopathology cases, allowing a rounded assessment of the liver status to be performed.
- This test code includes automatic application of special stains, reducing extended turnaround time from additional rework.
- Masson’s trichrome for assessing fibrosis
- Rubeanic acid for assessing copper status
- PAS for assessing glycogen
- Pathologists may request additional stains at their discretion on a case-by-case basis
Test code HISTLIV
The Histology Skin Profile test code was created to support clinicians with complex dermatological cases.
- This test code ensures that cases are automatically assigned to our group of pathologists with a specific interest in skin pathology and reduces extended turnaround time from additional rework.
- The test code includes examination of multiple sections of each biopsy sample and automatic application of special stains (Gram and PAS).
- Multiple biopsies from the same process can be submitted for a single fee.
- Please ensure that clinical history is included with the submission and indicate on the submission form if photos are being submitted.
- Photographs, if possible, can be submitted via email to labsupport@idexx.com and should include the patient name, your vet code and the date we can expect to receive the samples at the laboratory.
Test code HISTSK
The Histology GI Tract Profile is for the evaluation of endoscopic biopsy samples taken from the gastrointestinal tract of dogs and cats.
- Allows submission of multiple sites within the GI tract for one fee
- Oesophagus, stomach, small intestine, large intestine
- Sites are assessed and reported independently
- Samples are assessed and reported according to the WSAVA histopathological standards for the diagnosis of gastrointestinal inflammation
Test code HISTGI
Immunohistochemistry Panel
The immunohistochemistry report includes the following: antibodies utilised, the type of antigen or tissue marker detected, the results of the procedure(s) on the patient's tissues and an interpretative summary.
This service uses specialized immunohistochemical testing to demonstrate the presence of various antigens, aetiologic agents or tissue markers in histologic samples. Must have ordered a prior biopsy. If immunohistochemical studies would be helpful in a particular case, the pathologist will include a recommendation on the biopsy report to add on this test. Call us at 0203 7887 508 if you would like to initiate the studies.
Test codes IHCR1-IHCR7
See the online Directory of Tests and Services at vetconnectplus.co.uk
for test codes for additional sites/lesions.
Featured case
The whole spleen or subsampling?
Dale, a 10-year-old, neutered male bulldog, presented with an enlarged spleen. A splenectomy was performed, and his entire spleen was submitted to IDEXX Reference Laboratories as a Complex Biopsy (test code HISTLARGE). Upon receipt at the lab, the IDEXX histopathology technician performed a gross examination of the spleen and determined from which areas to obtain sample sections with the goal to obtain representative samples of the entire organ. Dale’s pathology report returned a haematoma and atypical lymphocyte proliferation. Dale's owner chose to monitor without treatment, and the dog remains well after 9 months. The case highlights the importance of submitting whole organs for pathology evaluation and utilising ancillary tests, like flow cytometry and PARR, for comprehensive diagnoses.
Practice support and pathology resources
Histology submission guidelines
IDEXX Learning Center education
Getting the Most Out of Your Biopsy Pathology Submissions
Getting the Most Out of Your Cytology Pathology Submissions
FAQs
The formalin to sample ratio should be 10:1, 10 parts of 10% buffered formalin to 1 part tissue. Please ensure the formalin completely covers the sample.
- If you have a sample that is too large to fit comfortably in the histology pots that IDEXX supply, we can provide packaging to transport the sample to the lab.
- Please go to idexx.co.uk/supplies to order.
- Ideally, please pre-fix the sample by placing in a container to soak in 10% neutral buffered formalin, 10:1 formalin to tissue ratio for at least 48 hours if possible. For spleens with diffuse enlargement, it may be possible to cut into 4 or 5 labelled sections and submit in standard pots. The bag we will provide for the sample is 30 cm in height and 28 cm wide. Please take standard precautions when handling the samples and formalin.
- Alternatively, please contact the laboratory and ask to speak to the anatomic pathologist on duty, to discuss the submission of your sample.
We do not recommend frozen tissue for histological interpretation as there will be loss of tissue architecture and considerable artefactual damage in the frozen sample. However, if you have already frozen tissue, and there is no other possibility of obtaining tissue for formalin fixation and histology, it may be possible to evaluate limited aspects of the tissue. If you have frozen tissue at your practice, cool down your formalin to 4 degrees, place sample in cooled formalin, and let it fix for 24 hours in the fridge. It is possible but not definite that you may have a useful sample, although any additional tests such as immunohistochemistry are unlikely to work.
View the formalin safety data sheet here or search 'formalin' in the IDEXX SDS portal to view additional materials.
Support
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sample guidelines
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IDEXX Reference Laboratory Support
We support your practice with our customer support, technical support and medical consulting services team, including our diagnostic support veterinary surgeons and board-certified veterinary specialists.
Call us at 02037 887-508
Monday through Friday: 08:30–17:00
Saturday: 09:00–13:00
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IDEXX Reference Laboratories
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Note: There may be times where weather or operational considerations cause delays in providing test results. When this happens, we will inform you as quickly as possible with the most complete information available.